Charlie Gard has died in hospice care.
Charlie's parents, Connie Yates and Chris Gard, fought a lengthy and emotional legal battle to take their severely ill baby son to the U.S. for treatment, which was denied by judges.
Charlie suffered from a rare genetic condition.
The Daily Mail reports Charlie's mother, Connie, said: "Our beautiful little boy has gone, we are so proud of you Charlie."
The BBC is also reporting the boy's death from a family spokesperson.
Baby Charlie was moved to a hospice following a court ruling on Thursday. His family had petitioned for the boy to be taken home, but were denied the request.