Marco Wilson and Isaiah Simmons scored touchdowns on two pick-6s late in the first half and used that stunning change in momentum to lift the Arizona Cardinals over the New Orleans Saints 42-34.

CeeDee Lamb had 122 yards from scrimmage, Tony Pollard had a 58-yard touchdown run and the Dallas defense produced timely sacks and turnovers in the Cowboys' 27-17 win over the New Orleans Saints.

Josh Allen passed for 260 yards and four touchdowns, Buffalo’s defense stifled New Orleans’ short-handed offense and the Bills rolled to a 31-6 victory that sent the injury-ravaged Saints to their fourth straight loss.

(AP Photo/Chris Szagola)In this strangest of NFL seasons in this weirdest of years, here's a matchup of division leaders you wouldn't expect: Seattle hosting the New York Giants. “If you win your division, you win your division,” Carroll says, and he knows: Seattle went 7-9 in 2010 and won the NFC West, then beat New Orleans in a playoff game. Patrick Mahomes has thrown for at least 300 yards seven times this season and has 22 straight games with at least one TD passing. New England has won the past five meetings, including a 2018 divisional playoff game. Chargers WR Keenan Allen leads the NFL with 85 receptions and has a TD catch in five straight games.

HOUSTON – The Houston Texans lost arguably the team’s top wide receiver and cornerback in a matter of hours. “It’s obviously unfortunate for our team,” said Watt. “Two of our better players on the team, obviously, so it’s unfortunate.”“It’s a situation that those two guys – they stuck up to what, I guess, went down with that. We’re going to miss those guys and those guys can be back and ready to go whenever that time is next season,” said Watson. The whole organization knows that, too,” said Watson.

HOUSTON – The Houston Texans are back in the win column, beating the Jacksonville Jaguars, the only team Houston hasn’t lost to this season. Deshaun Watson put up another huge game and the Texans defense did just enough against a rookie quarterback in his first start. Here are three takeaways from the win:Watson shows he still run itWatson hasn’t scrambled nearly as much this season. No Roby, big problemThe Texans missed Bradley Roby in a big way Sunday, giving up 304 yards to quarterback Jake Luton. Injuries pile upThe Texans came into the game missing three outside linebackers, who were on the COVID-19/Reserve list.

The Houston Texans and Jacksonvile Jaguars are both 1-6, with Houston’s only win coming against Jacksonville. This game will look a little different than the first game with the Jaguars bringing in a new quarterback. Johnson hasn’t broken 100 yards this year, but the closest he got came vs. Jacksonville in the Texans only win. The Texans are projected to win this game, and we all know Houston loves to run the ball on early downs (even to its detriment). Johnson had 17 carries vs. Jacksonville at NRG Stadium, and should get plenty of opportunities.

(AP Photo/Michael Conroy)Cleveland receiver Odell Beckham and Washington safety Landon Collins will have more tests Monday to determine the extent of what could be season-ending injuries. Beckham injured his left knee while attempting to make a tackle after Baker Mayfield threw an interception on the team's opening pass play. Collins injured his left ankle/Achilles tendon in noncontact fashion early in the second quarter. Phillips was carted off the field early in the second quarter. — Carolina left tackle Russell Okung (calf) left in the second half against New Orleans and did not return.

The Texans know Sunday’s game in Nashville against the Titans will test their true level of resilience. Some of the veterans on the team such as Bernardrick McKinney, Whitney Mercilus, and Johnathan Joseph all played for Vrabel. In their loss to the Broncos, the Texans did experience an offensive spark, but it was way too late. “You always want to throw the first punch and throw the last punch,” said Reid. Throw the first punch and the last punch.”Now, this team will try to throw the final punches of the season.