Wilson has 3 TDs before injury, 49ers crush Patriots 33-6

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San Francisco 49ers running back Jeff Wilson Jr. (30) spins to gains yardage behind the block of tackle Daniel Brunskill (60) in the first half of an NFL football game against the New England Patriots, Sunday, Oct. 25, 2020, in Foxborough, Mass. (AP Photo/Steven Senne)

FOXBOROUGH, Mass. – Jeff Wilson Jr. rushed for a career-high three touchdowns and 112 yards before leaving with an ankle injury and the San Francisco 49ers dominated in a 33-6 win over the New England Patriots on Sunday.

49ers quarterback Jimmy Garoppolo finished 20 of 25 for 277 yards with two interceptions in his first game against his former team. San Francisco (4-3) has followed back-to-back losses with two wins and is 3-0 on the road.

The Patriots' 27-point loss was their largest at home under Bill Belichick, according to Elias Sports Bureau. They had gone 286 games without a three-game losing streak, the longest span between three-game slides in NFL history. New England fell to 2-4 for the first since coach Belichick’s first season in 2000, when the Patriots went 5-11.

New England was outgained 467-241 in total yards.

San Francisco's Brandon Aiyuk had six catches for 115 yards and Deebo Samuel had five catches for 65 yards before leaving the game with a hamstring injury.

Patriots quarterback Cam Newton struggled throughout, completing 9 of 15 passes for 98 yards and three interceptions before being replaced by Jarrett Stidham in the fourth quarter. Stidham was 6 of 10 for 64 yards and an interception.

Newton was out of sync from the outset, making poor reads and poorer throws. But Garoppolo was successful in spreading out New England’s defense with a steady diet of passes behind the line scrimmage and jet sweeps to get the ball in the hands of Wilson, Samuel and George Kittle.

San Francisco dominated the first half, taking a 23-3 lead, holding the ball for 22:30, and racking up a 301-59 advantage in total yards. The Patriots also managed just four first downs to the 49ers’ 18.