Brock Purdy threw a career-high five touchdown passes and Dee Winters returned an interception 74 yards for a score to lead the San Francisco 49ers to a 48-27 victory at Indianapolis.

The AFC’s two top teams are home underdogs in Week 15.

Carolina Panthers safety Tre’von Moehrig has been suspended one game without pay for punching San Francisco 49ers wide receiver Jauan Jennings in the groin during Monday’s game.

Brock Purdy threw three touchdown passes in his return from a toe injury, Christian McCaffrey had two rushing touchdowns and a receiving score, and the San Francisco 49ers beat the sloppy Arizona Cardinals 41-22.

Josh Allen and the Buffalo Bills own Patrick Mahomes and the Kansas City Chiefs in the regular season.

C.

The NFL can see another worst to first turnaround this season.

The San Francisco 49ers have activated star tight end George Kittle from injured reserve.

Quarterback Brock Purdy has been ruled out for his third straight game for the San Francisco 49ers due to a toe injury.

The Philadelphia Eagles had a few extra days off to seethe and regroup after a humiliating loss to the Giants.

The NFL is more wide open than it’s been in years.

Four-time All-Pro linebacker Fred Warner will need season-ending surgery after he was sidelined by a severe ankle injury during San Francisco's loss to Tampa Bay.

Mac Jones is becoming the latest quarterback to prove he was dumped too soon.

Even the best quarterbacks look average or worse when they don’t have time to throw.

San Francisco star defensive end Nick Bosa tore the ACL in his right knee and will miss the rest of the season.

San Francisco 49ers star Nick Bosa left the win against the Arizona Cardinals with a knee injury.

The Kansas City Chiefs didn’t have to wait long for their Super Bowl rematch after a lopsided loss to the Philadelphia Eagles seven months ago.

San Francisco 49ers quarterback Brock Purdy is a "long shot" to play against the New Orleans Saints on Sunday due to a toe injury.

The San Francisco 49ers have waived kicker Jake Moody after he missed two field goals in the season opener.

It started with a friendship bracelet.

The NFL is banning the use of smelling salts during games, citing safety concerns and the potential to mask concussion symptoms.

The NFL often sees last-place teams bounce back to win their division, with 25 teams achieving this since 2002.

George Kittle has been voted as the NFL's top tight end by The Associated Press.

The San Francisco 49ers locked up another core player with a lucrative extension, agreeing to a three-year extension with All-Pro Fred Warner that makes him the highest-paid off-ball linebacker in NFL history.

George Kittle agreed to a four-year contract extension with the San Francisco 49ers that will make him the highest-paid tight end in NFL history.

Brock Purdy reported to the start of the offseason program for the San Francisco 49ers, while star tight end George Kittle stayed away from the start of the voluntary program.

Star tight end Trey McBride has agreed to a four-year deal with the Arizona Cardinals as the franchise locks up one of the NFL’s best young players through the 2029 season.

The opening of free agency for the San Francisco 49ers was more about their losses than their additions.

San Francisco 49ers tight end George Kittle is among the fans in attendance for the Sweden-Finland game at the 4 Nations Face-Off.

Vikings running back Aaron Jones, 49ers tight end George Kittle and Chargers defensive end Morgan Fox are the finalists for the NFL’s 14th annual Salute to Service award presented by USAA.

Lamar Jackson beat out Josh Allen, and Ja’Marr Chase and Justin Jefferson are unanimous choices for The Associated Press 2024 NFL All-Pro Team.

The defending NFC champion San Francisco 49ers were eliminated from the playoffs before their game at Miami began on Sunday because of victories by Washington and the Los Angeles Rams.

San Francisco coach Kyle Shanahan said linebacker De’Vondre Campbell won’t be part of the 49ers moving forward after he refused to enter a game after losing his starting job.

San Francisco linebacker De’Vondre Campbell refused to enter the game in the third quarter after losing his starting job when Dre Greenlaw returned from an injury.

Dallas Cowboys cornerback Trevon Diggs has apologized to a reporter over a confrontation about a social media post.

Brock Purdy threw a touchdown pass and ran for another score to send the San Francisco 49ers into their bye week on a high note with a 30-24 victory over the Dallas Cowboys.

Brock Purdy threw for 255 yards and three touchdowns, and the San Francisco 49ers never trailed in a 36-24 victory over the Seattle Seahawks.

Injuries already are accruing across the NFL, knocking several star players out and forcing teams to turn to backups and reserves.

Sam Darnold passed for 268 yards and two touchdowns against his former team, including a 97-yard strike in the second quarter to Justin Jefferson, and an attacking defense again fueled the Minnesota Vikings in a 23-17 victory over the San Francisco 49ers.

All the off-field attention that Travis Kelce generated last season while dating pop star Taylor Swift may have overshadowed his ability as a football player.

The San Francisco 49ers have no intention of granting star receiver Brandon Aiyuk his trade request and remain committed to getting a long-term extension done with one of their most important offensive players.

Travis Kelce and George Kittle are best of friends off the field and fierce competitors on it.

The Detroit Lions are just one win away from the first Super Bowl appearance in franchise history.

The four teams remaining in the NFL playoffs all have an aspect of their offense in common.

Christian McCaffrey, Tyreek Hill and Fred Warner are unanimous choices for The Associated Press 2023 NFL All-Pro Team.

Brock Purdy and Tua Tagovailoa were selected to their first Pro Bowl as the starting quarterbacks for their respective conferences.

The San Francisco 49ers and their deep group of playmakers accomplished a rare feat.

Brock Purdy threw three touchdown passes, including a 66-yarder to George Kittle, and the San Francisco 49ers seemingly fixed all their woes with a cross-country trip and a 34-3 drubbing of Jacksonville that ended a three-game skid.

Travis Kelce has spent more time in the headlines this season for his personal life than his football playing.

San Francisco 49ers tight end George Kittle has been fined more than $13,000 by the NFL for wearing a profane T-shirt about the Dallas Cowboys.

Brock Purdy threw three of his four touchdown passes to George Kittle and the San Francisco 49ers extended their dominance over the Dallas Cowboys with a 42-10 victory.

The San Francisco 49ers have given coach Kyle Shanahan and general manager John Lynch multi-year contract extensions.

Christian McCaffrey scored a touchdown in his 12th straight game, Brock Purdy threw two TD passes and the San Francisco 49ers won their 13th straight regular season game, 30-12 over the New York Giants.

The Kansas City Chiefs will have Patrick Mahomes under center after they raise their championship banner and embark on a quest to become the first team to repeat in nearly two decades.

Kansas City’s prolific pass catcher Travis Kelce has shattered numerous records over his 10-year career and was the unanimous choice by The Associated Press for the top spot among NFL tight ends.

Tight end Evan Engram and the Jacksonville Jaguars have agreed to a three-year, $41.25 million contract that includes $24 million guaranteed.

Snoop Dogg stepped up in an emergency during a weekend that saw World Wrestling Entertainment set a two-night attendance record for their signature event before being sold and Roman Reigns remaining the undisputed champion.

The San Francisco 49ers got a jolt offensively when they made the bold decision in October to trade four draft picks to add Christian McCaffrey to an already deep group of playmakers.

Four of the best tight ends in the NFL will be on display in Sunday's conference championship games.

Wild-card weekend is all about familiarity.

Brock Purdy threw three touchdown passes for his sixth straight game with multiple TDs and the San Francisco 49ers clinched the No. 2 seed in the NFC playoffs with a 38-13 victory over the Arizona Cardinals.

Brock Purdy threw two more long touchdown passes to George Kittle and the San Francisco 49ers beat the Washington Commanders 37-20 for their eighth straight win.

Jimmy Garoppolo threw four touchdown passes, including two each to Brandon Aiyuk and George Kittle, and the San Francisco 49ers won their third straight game by beating the Arizona Cardinals 38-10 in Mexico City.

The NFL Players Association is calling on six venues to change their current playing surfaces.

Christian McCaffrey became the 11th player in NFL history with a rushing touchdown, a passing touchdown and a receiving touchdown in one game, and the San Francisco 49ers extended their regular-season mastery over the Rams to four full years with a 31-14 victory over Los Angeles.

Patrick Mahomes threw for 424 yards and three touchdowns to rally Kansas City back from another double-digit deficit in the Chiefs’ 44-23 victory over the San Francisco 49ers.

General manager John Lynch still views his San Francisco 49ers as a Super Bowl contender despite a string of injuries, lackluster performances and a 3-3 start to the season.

The San Francisco 49ers have acquired star running back Christian McCaffrey from the Carolina Panthers for a haul of draft picks.

Can we finally start Tony Pollard.

Star tight end Darren Waller has agreed on a three-year contract extension with the Las Vegas Raiders.

No position in the NFL has undergone more changes to the style of player over the years than tight end.

Kyle Shanahan and Sean McVay arrived in California five years ago, a pair of hot-shot young coaches with a shared history and similar offenses taking over struggling franchises.

The San Francisco 49ers clinched a playoff spot with a 27-24 overtime victory over the NFC West champion Los Angeles Rams.

Rookie Trey Lance threw two touchdown passes in the second half of his second career start, and the San Francisco 49ers closed in on a playoff berth with a 23-7 victory over the Houston Texans.

Randy Bullock kicked a 44-yard field goal with 4 seconds remaining and the banged-up Tennessee Titans rallied from a 10-point halftime deficit to beat the San Francisco 49ers 20-17.

Jimmy Garoppolo threw a 12-yard touchdown pass to Brandon Aiyuk and the San Francisco 49ers beat the Cincinnati Bengals 26-23 in overtime.

Russell Wilson played his best game since returning from finger surgery by throwing for 231 yards and two touchdowns and the Seattle Seahawks made a late goal line stand to beat the San Francisco 49ers 30-23.

Jimmy Garoppolo threw two touchdown passes for the third consecutive week and the San Francisco 49ers dominated Jacksonville 30-10 on Sunday for their third win in four games.

Jimmy Garoppolo threw two touchdown passes, Jimmie Ward returned one of his two first-quarter interceptions for another score and the San Francisco 49ers beat the Los Angeles Rams 31-10 for their first home win in more than a year.

James Conner ran for two touchdowns and caught a 45-yard TD pass from backup quarterback Colt McCoy as the short-handed Arizona Cardinals beat the San Francisco 49ers 31-17.

Rookie quarterback Trey Lance will make his first start for the San Francisco 49ers after Jimmy Garoppolo was ruled out of this week’s game with a calf injury.

Jimmy Garoppolo threw one touchdown pass and ran in for a score, leading the San Francisco 49ers to a 17-11 victory over the Philadelphia Eagles.

Dre Greenlaw returned an interception for a touchdown to help the San Francisco 49ers score 17 points over two-plus minutes late in the first half and they held on for a 41-33 win over the Detroit Lions.

Aaron Rodgers and Deshaun Watson appeared on the field at their teams’ first training camp practices.

From players getting COVID-19 vaccinations to relaxed coronavirus protocols to lineup issues, particularly at quarterback, the NFL faces a multitude of questions as training camps open.

FILE - San Francisco 49ers offensive tackle Trent Williams (71) looks on prior to an NFL football game against the Arizona Cardinals, in Glendale, Ariz., in this Saturday, Dec. 26, 2020, file photo. The San Francisco 49ers locked up their biggest potential free agent for the long term by agreeing to give star left tackle Trent Williams the richest contract ever for an offensive lineman. (AP Photo/Jennifer Stewart, File)SANTA CLARA, Calif. – The San Francisco 49ers locked up their biggest potential free agent for the long term by agreeing to give star left tackle Trent Williams the richest contract ever for an offensive lineman. “Trent’s a game changer,” said fullback Kyle Juszczyk, who signed a five-year contract to stay in San Francisco earlier in the week. Williams was graded as the top left tackle by Pro Football Focus and is now being paid that way as well.

It seemed even fewer showed up to do their shows at socially distanced tables at the Super Bowl Media Center inside the Tampa Convention Center. “We still had live guests, including live guests from the Chiefs and Buccaneers. “Radio Row is a spectacle every year that has a buzz and excitement for media, athletes and sponsors,” Onaindia said. One of the benefits of Radio Row is the organic networking that happens between everyone in attendance. We all missed that this year.”The idea of Radio Row at the Super Bowl originated in 1992 in Minneapolis when New York’s WFAN broadcast on-site from a local hotel.

(AP Photo/Scott Eklund)George Kittle dismissed talk about the San Francisco 49ers possibly trading Jimmy Garoppolo the way he sheds tacklers after making catches. I think it’s chatter,” Kittle said on the AP Pro Football Podcast. “I think it’s his second or third year of dealing with these exact same rumors every single offseason,” Kittle said. Garoppolo, Kittle, cornerback Richard Sherman, edge rusher Nick Bosa, running back Raheem Mostert and receiver Deebo Samuel all missed at least half the season. I think that was a struggle for us, especially because we have a young team on offense as well.

Kansas City Chiefs tight end Travis Kelce is tackled by Atlanta Falcons Foyesade Oluokun during the first half of an NFL football game, Sunday, Dec. 27, 2020, in Kansas City. The Chiefs had to watch as Pro Bowl kicker Younghoe Koo missed a tying field-goal attempt with 9 seconds left to escape. The Falcons (4-11) took the lead when Matt Ryan hit Laquon Treadwell for a 5-yard touchdown with 4:33 to go. Kansas City finally took its first lead on Harrison Butker's 53-yard field goal with 14:08 left in the game. The Falcons squandered their first chance to match the points when Brandon Powell coughed up the ball deep in Kansas City territory.

The Niners will fly to Arizona, where they will practice, live and play their next two games after Santa Clara County imposed a three-week ban on games and practices for contact sports. (AP Photo/Ross D. Franklin, File)The San Francisco 49ers will finish out the regular season practicing and playing home games in Arizona after a ban on contact sorts in their home county was extended into January. The Niners relocated to Arizona at the beginning of December after Santa Clara County announced a three-week ban on contact sports games and practices to help slow the spread of the coronavirus. And, I think a lot of people are in the same boat.”The 49ers arrived in Arizona on Dec. 2 and began practicing the next day. The team is staying at a hotel near the Arizona Cardinals stadium in Glendale, where they are playing their home games.

The New York Giants and Minnesota Vikings are in position to pull off remarkable turnarounds. One of the other teams that started 0-5 this season shares a stadium with the Giants but hasn’t pulled off an in-season turnaround. Jefferson, a first-round pick, had nine catches for 121 yards last week to reach 1,039 yards receiving on the season. With 11 TD runs this season, Newton has reached double-digits in three seasons (14 in 2011 and 10 in 2015). It was the first time since Brady Quinn in 2009 that a quarterback won consecutive starts despite throwing for fewer than 100 yards.

From the season-altering (Dak Prescott, Barkley) to the bizarre (Tyrod Taylor, Trent Brown), injuries are playing their traditionally significant role in the NFL. (AP Photo/Charles Rex Arbogast, File)ARLINGTON, Texas – From the season-altering to the bizarre, injuries are playing their traditionally significant role in the NFL. Brown also recently went back on the COVID-19 list, a newcomer among potential ailments with the NFL playing during a pandemic. Few teams have had the volume of injuries that have hit defending NFC champion San Francisco. New Orleans' star receiver, Michael Thomas, has had a tumultuous season in part because of ankle and hamstring injuries.

Green Bay Packers quarterback Aaron Rodgers (12) is congratulated by running back Aaron Jones (33) after throwing a touchdown pass to Marcedes Lewis during the first half of an NFL football game against the San Francisco 49ers in Santa Clara, Calif., Thursday, Nov. 5, 2020. (AP Photo/Jed Jacobsohn)SANTA CLARA, Calif. – Aaron Rodgers threw for 305 yards and four touchdowns and the Green Bay Packers overwhelmed the undermanned San Francisco 49ers 34-17 on Thursday night. Rodgers and the Packers, who were missing three players on the COVID-19 list, took advantage of the opportunity. DEPLETED ROSTERThe run of injuries and coronavirus rules left the 49ers with a shell of a roster, especially on offense. 49ers: CB K’Waun Williams (ankle) and S Jaquiski Tartt (foot) left the game and didn’t return.

Miami Dolphins quarterback Tua Tagovailoa (1) and quarterback Ryan Fitzpatrick (14) embrace after Tagovailoa throws his first touchdown pass during an NFL game against the Los Angeles Rams, Sunday, Nov. 1, 2020 in Miami Gardens, Fla. (Margaret Bowles via AP)When the Dolphins leave the oceanfront and head to the desert to play the Cardinals on Sunday, it will be about more than Tua vs. Kyler. Tua Tagovailoa, as touted as any signal caller coming out of college in years, will make his second start for Miami. Henry has eight rushing touchdowns, finding the end zone in five straight games. The Patriots will try to avoid losing five straight games for the first time since 1995.

(AP Photo/Elaine Thompson)SANTA CLARA, Calif. – The San Francisco 49ers will be without quarterback Jimmy Garoppolo and All-Pro tight end George Kittle for an extended period of time after they got hurt against Seattle. A person familiar with the injuries said Monday on condition of anonymity that Garoppolo’s ankle injury and Kittle’s foot injury will sideline them indefinitely. San Francisco already has been forced to play without defensive ends Nick Bosa, Dee Ford and Solomon Thomas; top cornerback Richard Sherman, No. He hurt his shoulder in New England in 2016 and had a season-ending injury for San Francisco in 2018. San Francisco also traded linebacker Kwon Alexander to New Orleans on Monday in exchange for linebacker Kiko Alonso and a conditional fifth-round draft choice.

Wilson threw four more touchdown passes, two to Metcalf, and the Seahawks rebounded from their first loss of the season with a resounding 37-27 win over the San Francisco 49ers on Sunday. Wilson and Metcalf tormented San Francisco and its banged up secondary as the top-scoring offense in the league continued to pile up points. Wilson found rookie DeeJay Dallas on a 2-yard TD pass after San Francisco went three-and-out to open the second half for a 20-7 lead. The momentum from two straight wins for San Francisco (4-4) evaporated in a hurry as more injuries continued to pile. San Francisco played without starters Deebo Samuel, Jeff Wilson Jr., Kwon Alexander and safety Jaquiski Tartt.

– Jeff Wilson Jr. rushed for a career-high three touchdowns and 112 yards before leaving with an ankle injury and the San Francisco 49ers dominated in a 33-6 win over the New England Patriots on Sunday. San Francisco (4-3) has followed back-to-back losses with two wins and is 3-0 on the road. New England fell to 2-4 for the first since coach Belichick’s first season in 2000, when the Patriots went 5-11. Following a Patriots punt, San Francisco was pinned inside its 15. The lead grew to 23-3 with just under a minute to go before halftime on a 16-yard run by Wilson.

Garoppolo threw three TD passes in the first half and Jason Verrett’s first interception in more than four years helped preserve the lead, giving the 49ers a 24-16 victory over the Los Angeles Rams on Sunday night. This week got us back on track.”San Francisco’s defense stepped up with some key stops in the second half. Verrett's interception was part of a rough day overall for Jared Goff, who also missed an open Kupp on a deep ball earlier in the second half. Garoppolo found Kittle on a one-on-one matchup with Darious Williams on a fourth-and-2 play that turned into a 44-yard TD. INJURY REPORT49ers: RB Raheem Mostert (ankle) S Jaquiski Tartt (groin) and C Ben Garland (calf) all left in the second half and didn't return.

(AP Photo/Jed Jacobsohn)SANTA CLARA, Calif. – A couple of unlikely players helped deliver the Philadelphia Eagles their first win of the season. Travis Fulgham caught a go-ahead 42-yard touchdown pass from Carson Wentz with 5:50 remaining and Alex Singleton returned an interception for a score to lift the Eagles to a 25-20 win over the San Francisco 49ers on Sunday night. But Fulgham got past backup cornerback Dontae Johnson and Wentz delivered a perfectly placed pass for the score that gave Philadelphia an 18-14 lead. It’s a resilient group.”TAKE IT AWAYThe Eagles got their first defensive takeaway of the season thanks to a poor decision by Mullens. With the Niners in the red zone, Mullens threw a ball up for grabs while under pressure and Rodney McLeod came up with it.

Jeudy is active for the Bucs game as Denver quarterback Jeff Driskel makes his first start while Drew Lock recovers from a shoulder injury. Cardinals: QB Brett Hundley, WR Christian Kirk, RB Eno Benjamin, OL Mason Cole, OL Josh Miles, DL Leki Fotu. ___CHICAGO AT ATLANTABears: CB Duke Shelley, OG Arlington Hambright, NT Daniel McCullers, WR RIley Ridley, OLB Trevis GipsonFalcons: WR Julio Jones, CB A.J. Browns: WR Donovan Peoples-Jones, CB Greedy Williams, LB Jacob Phillips, Olivier Vernon, Evan Brown and WR Rashard Higgins. Brown, CB Chris Jackson OLB Derick Roberson, C Aaron Brewer, TE Geoff Swaim, DT Matt DickersonVikings: WR Tajaé Sharpe, WR K.J.