Two-time Wimbledon champion Andy Murray has lost in the second round to big-serving American John Isner.
Novak Djokovic has taken another step toward regaining his top form with a 6-3, 6-2 win over Aslan Karatsev in his opening match at the Italian Open.
Daniil Medvedev never gave Andy Murray a chance.
Olympic gold medalist Alexander Zverev advanced to the third round at the Australian Open and continued a streak at Grand Slam tournaments by beating Australian veteran John Millman 6-4, 6-4, 6-0.
Serena Williams is out of Wimbledon after she stopped playing her first-round match because of a right leg injury.