HOUSTON – Regular and thorough handwashing is necessary to help prevent the spread of disease -- but it can also lead to dry, cracked skin. “Not applying hand cream can lead to dryness, redness, itching, flaking, discomfort and in severe cases, cracks in the skin. Wash with warm, not hot water, for at least 20 seconds, patting your hands dry with a towel. Once your hands are dry, apply a moisturizer immediately,” said Ingraham, who stresses about putting the moisturizer on top of your hands, fingertips and knuckles. young woman putting moisturizer onto her hand with very dry skin and deep cracks (iStock)To care for dry skin, keep in mind that products containing fragrance, acids or retinoids can be irritating to chapped, sensitive skin.