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WATCH: A look at some of NASA’s most important missions as humans prepare to return to the Moon on Artemis II

The NASA Artemis II SLS (Space Launch System) rocket with the Orion spacecraft is seen at Launch Complex 39B at the Kennedy Space Center, Tuesday, March 31, 2026, in Cape Canaveral, Fla. (AP Photo/John Raoux) (John Raoux, Copyright 2026 The Associated Press. All rights reserved)

For the first time in more than 50 years, humans are preparing to travel beyond low-Earth orbit and return to the Moon.

Artemis II, NASA’s first crewed test flight in its return-to-the-Moon program, is set to blast off at 5:24 CDT on Wednesday.

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Four astronauts are slated to orbit the moon in their Orion capsule before heading back to Earth.

This is the first time human beings have gone so far into space since the Apollo-era.

Ahead of Wednesday’s historic launch, we are taking a look back at some of the most important missions of NASA.

Apollo 11

What better place to start this list than to look back at the very first time humans set foot on the moon.

At the time, the United States and the Soviet Union were engaged in a Space Race, constantly working to outpace and outperform the other world power in terms of achievements and innovation.

After the shock of the Soviets launching the first artificial satellite with Sputnik-1 in 1957 and cosmonaut Yuri Gagarin becoming the first human in space on April 12, 1961, President John F. Kennedy presented a bold plan to Congress.

** FOR USE WEDNESDAY, MAY 25 AT 12:01 A.M. EDT. THIS PHOTO CANNOT BE PUBLISHED IN PRINT, ONLINE OR FOR BROADCAST BEFORE MAY 25 AT 12:01 A.M. EDT ** FILE - In this May 25, 1961 file photo, President John F. Kennedy speaks in the House of Representatives before a joint session of Congress in Washington. In the background are Vice President Lyndon B. Johnson, left, and House Speaker Sam Rayburn. During that speech, Kennedy issued the challenge for NASA to send a man to the moon. That challenge that was met on July 20, 1969, when Apollo 11's lunar module landed on the moon. (AP Photo, File) (AP1961)

“First, I believe that this nation should commit itself to achieving the goal, before this decade is out, of landing a man on the moon and returning him safely to the earth,” President Kennedy said to Congress on May 25, 1961.

The United States committed itself to President Kennedy’s vision and the Apollo program was dedicated to Kennedy’s goal.

Fast forward to July 1969, three astronauts, Neil Armstrong, Buzz Aldrin and Michael Collins, the Apollo 11 crew, blasted off towards the moon.

Apollo Moon Landing Astronaut Neil Armstrong did something no one had ever done before. On July 20, 1969, he set foot on the moon. Photograph is courtesy of NASA History Office and the NASA JSC Media Services Center.

On July 20, Armstrong made history, becoming the first human being to step foot on the moon’s surface.

“That’s one small step for a man, one giant leap for mankind,” he said as millions of people watched the historic moment on television.

Over the next three and a half years, 10 other astronauts would follow in the crew of Apollo 11’s footsteps and also step foot on the moon.

Hubble Space Telescope

Launched and deployed by the space shuttle Discovery in 1990, the Hubble Space Telescope has changed and challenged humans understanding of the cosmos.

This photo provided by NASA, an STS-125 crew member aboard the Space Shuttle Atlantis captured this image of NASAs Hubble Space Telescope on May 19, 2009. NASA said the telescope slipped into a hibernating state more than a week ago when one of its gyroscopes _ part of the pointing system _ malfunctioned. The same device has been acting up for months and disrupting scientific operations. Hubble remains safe but inactive as flight controllers figure out how to proceed, officials said. The space agency planned to outline a path forward on Tuesday, June 4, 2024.(NASA via AP)

According to NASA, Hubble has made more than 1.7 million observations over the course of its lifetime. Over 22,000 peer-reviewed science papers have been published on its discoveries, and every current astronomy textbook includes contributions from it.

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The images Hubble has captured in space are stunning and beautiful, but are much more than just pretty pictures.

Hubble has captured both the birth and death of stars. detected planets outside our solar system, observed evidence of black holes, and so much more.

Astronomers using NASA's Hubble Space Telescope captured the quick, fading celebrity status of a supernova, the self-detonation of a star. The supernova, called SN 2018gv, appears in the lower left portion of the frame as a blazing star located on the outer edge of spiral galaxy NGC 2525, located 70 million light-years away. (NASA, ESA, and A. Riess (STScI/JHU) and the SH0ES team; acknowledgment: M. Zamani (ESA/Hubble))

To dive deep into all the discoveries Hubble has been responsible for would be impossible to do with an article like this. For this reason alone, it deserves to be talked about as one of the most important missions and scientific achievements NASA has been responsible for.

The Space Shuttle Program

NASA’s space shuttle program had its first launch on April 12, 1981 and continued through 2011.

Space Shuttles Columbia, Challenger, Discovery, Atlantis and Endeavor carried people into orbit, recovered and repaired satellites, launched the Hubble Space Telescope, and helped build the International Space Station.

Space shuttle Atlantis launches from pad 39A on Friday, July 8, 2011, at NASA's Kennedy Space Center. The launch of Atlantis, STS-135, was the final flight of the shuttle program, a 13-day mission to the International Space Station. (Photo: NASA)

The spacecrafts became platforms for scientific research and its legacy of being a reusable spacecraft with an innovative design will continue to endure because of the achievements it made not just for a singular country, but the world.

However, its discoveries and achievements were shadowed by the loss of both Columbia and Challenger.

The space shuttle Challenger is destroyed shortly after lifting off, Tuesday, Jan. 28, 1986, at the Kennedy Space Center in Florida. The crew of seven, including NASA's first teacher in space Christa McAuliffe, died in the explosion. (AP Photo/Bruce Weaver, File) (1986 AP)

On January 28, 1986, Space Shuttle Challenger exploded 73 seconds into its flight, killing all seven crew members.

FILE - Debris from the space shuttle Columbia streaks across the Texas sky as seen from Dallas on Saturday, Feb. 1, 2003. NASA marked the 20th anniversary of the tragedy with somber ceremonies and remembrances during its annual tribute to fallen astronauts on Thursday, Jan. 26, 2023. (AP Photo/Jason Hutchinson/file) (AP2003)

On February 1, 2003, Space Shuttle Columbia broke apart as it re-entered the earth’s atmosphere. All seven crew members aboard perished.

Despite the losses, the space shuttles flew a combined 135 missions until they were all officially retired on July 21, 2011. It will be remembered as the vessel called upon to help build the International Space Station (ISS), the largest spacecraft ever assembled.

Apollo 13

FILE - In this April 11, 1970 file photo, crowds watch the lift-off of the Saturn V rocket carrying the Apollo 13 spacecraft on its mission to the moon from Cape Kennedy, Fla. (AP Photo) (AP1970)

Launched on April 11, 1970, what was meant to be the third lunar landing took a dangerous turn when an oxygen tank exploded during the Apollo 13 mission.

Astronauts Jim Lovell, Fred Haise, and Jack Swigert were on their way to the moon when the explosion occurred. The crew noticed the explosion had damaged the second oxygen tank aboard the craft and they were losing the very thing that would keep them alive.

The explosion and damage made use of the crafts fuel cells impossible and threatened the eventual loss of all electrical power and water.

Mission Control erupts into cheers and applause as the Apollo 13 astronauts return to Earth. (NASA)

Working closely with Mission Control at Houston’s Johnson Space Center, the crew of Apollo 13 was able to figure out how to return to earth safely.

Despite the disappointment with not being able to land on the moon, the mission was regarded as an “successful failure” because all three astronauts were brought back to earth safely.