Two 18-wheelers collided and a car driver is being blamed for causing the chain-reaction accident.
It happened on the Southwest Freeway and Beechnut around 11:45 p.m. Wednesday.
There is construction in the area, that has closed some of the lanes.
Investigators say a car pulled in front of an 18-wheeler, causing the truck driver to lose control, hit the car and slam into another 18-wheeler.
A pickup couldn't avoid the accident and ended up hitting the side of the 18-wheeler.
The 18-wheeler's driver was taken to the hospital in stable condition.
No one else was hurt.