Highway 146 has reopened at Highway 96 near Galveston Bay after an accident involving two 18-wheeler and three other vehicles.
It happened around 8 a.m. Monday, according to Houston TranStar.
Kemah police said two people were transported to an area hospital in unknown conditions.
Officials said a hazmat crew responded to the scene to clean up the fuel spill.
Highway 146 reopened to traffic around 12:20 p.m.