Caroline Kennedy was confirmed late Wednesday as the new U.S. ambassador to Japan, after being nominated by President Obama in July.
She is the last surviving member of former president John F. Kennedy's immediate family.
Kennedy replaces John Roos, who assumed the role in 2009 and was the first American ambassador to attend commemoration ceremonies for the American atomic bombings of Hiroshima and Nagasaki.
After receiving degrees at Harvard and Columbia, Kennedy served in a variety of roles at nonprofits, including the John F. Kennedy Library and the American Ballet Theatre. She has said she will resign from her non-profit positions upon taking up her new role.
Kennedy was a top supporter of President Obama and co-chaired his vice president search committee in 2008.